Multi-objective optimization identifies a specific and interpretable COVID-19 host response signatureArticle Published on 2022-12-212023-07-11 Journal: Cell Systems [Category] COVID19(2023년), [키워드] COVID-19 cross-reactivity epigenomics host response signature interpretability optimization plasmablasts robustness transcriptomics viral infection diagnosis. [DOI] 10.1016/j.cels.2022.11.008 PMC 바로가기
The pH Robustness of Bacterial SensingArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] 유전자 메커니즘, [키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction signal transduction. Signaling TAR tested ultracentrifugation was obtained [DOI] 10.1128/mbio.01650-22 PMC 바로가기
Estimating SARS-CoV-2 variant fitness and the impact of interventions in England using statistical and geo-spatial agent-based models통계 및 지리 공간 에이전트 기반 모델을 사용하여 SARS-CoV-2 변종 적합도 및 영국에서의 개입 영향 추정Article Published on 2022-10-032022-09-11 Journal: Philosophical transactions. Series A, Mathematical [Category] COVID19(2023년), SARS, 변종, [키워드] agent agent-based model Alpha B.1.1.7 B.1.177 death distribution dominant variant effective England Epidemics estimate Evolution example geo-spatial model Intervention Lineage lockdown lockdowns prevented relative reopening replaced REPLACED BY Reproduction number robustness SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 variant Spread statistical statistical model the epidemic Transmissibility vaccination Vaccinations variant variants Variation Viral variants virus variants virus variants. [DOI] 10.1098/rsta.2021.0304 PMC 바로가기 [Article Type] Article
VOC-DL: Deep learning prediction model for COVID-19 based on VOC virus variantsVOC-DL: VOC 바이러스 변종 기반 코로나19 딥 러닝 예측 모델Article Published on 2022-09-012022-09-11 Journal: Computer methods and programs in biomedicine [Category] 변종, [키워드] Accuracy affected analyzed average concern confirmed case confirmed cases country COVID-19 dataset datasets deep deep learning develop experimental results FIVE framework highest India information Italy Japan long term LSTM medium other variant other variants pandemic predict prediction Predictive Region robustness Russia South Korea stability time Time series Transmission variant Variant. variants virus variant virus variants VoC VOC-DL model [DOI] 10.1016/j.cmpb.2022.106981 PMC 바로가기 [Article Type] Article
Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycleSARS-CoV-2 스파이크 단백질 요소와의 Decavanadate 상호 작용은 감염 주기를 방해하는 정전기의 잠재적 역할을 강조합니다Article Published on 2022-09-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral agent approach association binding biological properties biological property carried collected data coronavirus COVID-19 cytotoxicity decrease disrupt disrupting drug design effective Effectiveness effort electrostatic force electrostatic forces element ENhance Evidence furin furin cleavage site highlight Host host cell host cell membrane identify In vitro studies in vitro study infected cells Interaction interactions less mass spectrometry molecular Native Novel coronavirus Polyanion polybasic Polyoxidometalate Protein Protein binding Proteolytic processing provide receptor Receptor-binding domain robust robustness Safe SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 spike protein shown Spike protein the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic therapeutic agent therapeutic agents Therapeutics utility Vanadium Vanadium. variety Viral mutations while [DOI] 10.1016/j.jinorgbio.2022.111899 PMC 바로가기 [Article Type] Article
Mobility was a significant determinant of reported COVID-19 incidence during the Omicron Surge in the most populous U.S. Counties이동성은 미국에서 가장 인구가 많은 카운티에서 Omicron Surge 동안 보고된 COVID-19 발병의 중요한 결정 요인이었습니다.Article Published on 2022-08-152022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval categories Cohort contrary Course covariates COVID-19 COVID-19 incidence cross-sectional analysis cumulative declined Epidemics exhibiting fatigue fraction Google Google mobility reports household size humans Immune escape incidence infect Infection intrinsic Mobility omicron Omicron variant peaked Perceived risk Principal component principal component analysis principal components question reported risk-mitigating behavior. robustness SARS-CoV-2 Significant susceptible individual susceptible individuals vaccination variant widespread [DOI] 10.1186/s12879-022-07666-y PMC 바로가기 [Article Type] Article
Effectiveness and Cost-Effectiveness of Inactivated Vaccine to Address COVID-19 Pandemic in China: Evidence From Randomized Control Trials and Real-World Studies중국의 코로나19 팬데믹에 대처하기 위한 비활성화 백신의 효과 및 비용 효율성: 무작위 대조 시험 및 실제 연구의 증거Meta-Analysis Published on 2022-07-192022-09-11 Journal: Frontiers in Public Health [Category] 임상, [키워드] 95% CI address Analysis BBIBP-CorV China Chinese clinical trial CNKI combating Control CoronaVac cost-effectiveness COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine death determine effective Effectiveness Efficacy Evidence Factor Hospitalization hospitalizations ICU admission ICU admissions immunization inactivated Inactivated COVID-19 vaccine Inactivated vaccine Inactivated Vaccines infections International Medical cost Meta-analysis Perspective prevented Probability RCT real-world evidence. Result robust robustness sensitivity analysis the vaccine vaccination Vaccine vaccine efficacy was performed Web of Science website were used [DOI] 10.3389/fpubh.2022.917732 PMC 바로가기 [Article Type] Meta-Analysis
Ligand-based and structure-based studies to develop predictive models for SARS-CoV-2 main protease inhibitors through the 3d-qsar.com portal3d-qsar.com 포털을 통해 SARS-CoV-2 주요 프로테아제 억제제에 대한 예측 모델을 개발하기 위한 리간드 기반 및 구조 기반 연구Article Published on 2022-07-012022-09-11 Journal: Journal of computer-aided molecular design [Category] COVID19(2023년), SARS, 치료제, [키워드] 3-D QSAR Analysis applicability approach binding binding energy build calculation Candidates cleavage site co-crystallized Combination COMBINE Compound conservation coronavirus COVID-19 infected patients develop domain drug design Emergency use authorization enzyme EUA feature Final functional protein implicated in viral inhibitor inhibitors joint Ligand ligand-based drug design M pro maturation Metrics Mild-to-moderate Model molecular Nirmatrelvir outcome performed portal Predictive Predictive model promote protease Quantitative reached Replication reported resources robust robustness safety profile SARS-CoV-2 SARS-CoV-2 main protease statistical Structure-activity relationships structure-based drug design. tolerable training set Transcription Treatment U.S. FDA viral replication Virtual screening [DOI] 10.1007/s10822-022-00460-7 PMC 바로가기 [Article Type] Article
Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infectionSARS Cov2 원형, Delta 및 Omicron 변이체 감염을 억제하는 잠재적인 COVID-19 치료 화합물의 식별Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료법, 치료제, [키워드] Anti-viral drug repurposing apilimod approach approach berbamine candidate drug cell death Cepharanthine clinical trial clinically Compound compounds COVID-19 COVID19 crizotinib Delta drug drug candidate effort FDA approval followed by Health identification Infection inhibit inhibited inhibitory effect less library multiple cell lines omicron Omicron variant Omicron variants Probability pseudovirus entry Recurrent replicated repurposing required robustness safety profile SARS CoV2. screened stratified Treatment Validity variant [DOI] 10.1016/j.virol.2022.05.004 PMC 바로가기 [Article Type] Article
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다Review Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Administered analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine vaccine. viral replication X-linked [DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review